![]() ![]() ![]() In 2021, the number of individuals who lived with diabetes globally was around 537 million (IDF, 2021), with the amount anticipated to rise to 642 million diabetic people by 2040 (Colagiuri, 2010). The prevalence of diabetes is growing every year. Consumption of Hibiscus tea or juice may be a potential source for developing an anti-diabetic drug. ![]() sabdariffa's potential to protect against oxidative damage and the complications associated with diabetes. sabdariffa extracts demonstrated the ability to inhibit carbohydrate digesting enzymes, facilitate muscle glucose uptake and attenuate oxidative stress in oxidative hepatic injury. sabdariffa has been used to treat diabetes in traditional medicine. This has instigated a radical shift towards the use of traditional plants, which are rich in phytochemicals many years ago. In recent years, there has been increased concern about the side effects of synthetic anti-diabetic drugs, as well as their expensive cost, especially in impoverished nations. sabdariffa has promising antioxidant and antidiabetic activity. The molecular docking displayed the compound 4-(3,5-Di-tert-butyl-4-hydroxyphenyl)butyl acrylate strongly interacted with α-glucosidase and α-amylase and had the lowest free binding energy compared to other compounds and acarbose. The extract revealed the presence of several phenolic compounds when submitted to gas chromatography–mass Spectroscopy (GC–MS) screening, which was docked with α-glucosidase and α- amylase. The extract of the plant inhibited intestinal glucose absorption and increased muscular glucose uptake. sabdariffa significantly ( p < .05) raised reduced glutathione (GSH) levels while simultaneously decreasing malondihaldehyde (MDA) and NO levels and increasing superoxide dismutase (SOD) and catalase activity in Fe 2+ induced oxidative hepatic injury. The extracts significantly suppressed α-glucosidase and α-amylase activities ( p < .05), with the ethanolic extract demonstrating the highest activity. When compared to ethyl acetate and aqueous extracts, the ethanolic extract displayed the most potent scavenging activity in ferric-reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and nitric oxide (NO) assays, with IC 50 values of 2.8 μl/ml, 3.3 μl/ml, and 9.2 μl/ml, respectively. The oxidative damage was induced in hepatic tissue by incubation with 0.1 mMolar ferrous sulfate (FeSO4) and then treated with different concentrations of crude extracts (ethyl acetate, ethanol, and aqueous) of H. In this current study, the antidiabetic effectiveness of Hibiscus sabdariffa and its protective function against Fe 2+-induced oxidative hepatic injury were elucidated using in vitro, in silico, and ex vivo studies. ![]()
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